Article
MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML.
Blood - 4 Oct 2018
Sanders Mathijs A, Chew Edward, Flensburg Christoffer, Zeilemaker Annelieke, Miller Sarah E, Al Hinai Adil S, Bajel Ashish, Luiken Bram, Rijken Melissa, Mclennan Tamara, Hoogenboezem Remco M, Kavelaars François G, Fröhling Stefan, Blewitt Marnie E, Bindels Eric M, Alexander Warren S, Löwenberg Bob, Roberts Andrew W, Valk Peter J M, Majewski Ian J
Abstract excerpt
The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a major role in shaping the human genome, and this methylation damage remains the primary source of somatic mutations that accumulate with age. How 5mC deamination contributes to cancer risk in different tissues remains unclear. Genomic profiling of 3 early-onset acute myeloid leukemias (AMLs) identified germ line loss of MBD4 as an...
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