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Article

Antibody‐mediated complement activation in pathology and protection

6 Mar 2020

Abstract excerpt

Antibody-dependent complement activity is associated not only with autoimmune morbidity, but also with antitumor efficacy. In infectious disease, both recombinant monoclonal antibodies and polyclonal antibodies generated in natural adaptive responses can mediate complement activity to protective, therapeutic or disease-enhancing effect. Recent advances have contributed to the structural resolution of molecular...

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PMID: 32142167
DOI: 10.1111/imcb.12324

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