Article

A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates

2023-09-04

Abstract excerpt

Ubiquitination of proteins is central to protein homeostasis and other cellular processes including DNA repair, vesicular transport, cell-division etc. The process of ubiquitination is conserved from yeast to humans and is carried out by the sequential action of three enzymes: E1, E2 and E3. There are an estimated >600 E3 ligases in humans that execute ubiquitination of specific target proteins in a spatio-tempora...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bacbdff1-f3f3-5e71-a082-137d97bc55ff
DOI: 10.1101/2023.09.04.556194

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substratesDOI 10.1101/2023.09.04.556194Read

BioE3 identifies specific substrates of ubiquitin E3 ligasesSemantic proximity Read

Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processesSemantic proximity Read

An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like moleculesSemantic proximity Read

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 FunctionSemantic proximity Read

AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions.Semantic proximity Read

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.Semantic proximity Read

Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6Semantic proximity Read

Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.Semantic proximity Read

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.Semantic proximity Read

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.Semantic proximity Read

<i>In vivo</i> discovery of RNA proximal proteins in human cells via proximity-dependent biotinylationSemantic proximity Read

Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice.Semantic proximity Read