Article
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
Molecular cell - 27 Aug 2010
Matic Ivan, Schimmel Joost, Hendriks Ivo A, van Santen Maria A, van de Rijke Frans, van Dam Hans, Gnad Florian, Mann Matthias, Vertegaal Alfred C O
Abstract excerpt
Reversible protein modification by small ubiquitin-like modifiers (SUMOs) is critical for eukaryotic life. Mass spectrometry-based proteomics has proven effective at identifying hundreds of potential SUMO target proteins. However, direct identification of SUMO acceptor lysines in complex samples...
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