Article

WNK1 regulates uterine homeostasis and its ability to support pregnancy

2020-03-29

Abstract excerpt

WNK1 is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans which is associated with abnormal ion homeostasis. Our earlier findings demonstrated that WNK1 is critical for in vitro decidualization in human endometrial stromal cells – pointing towards an unrecognized role of WNK1 in female reproduction. Here, we employed a mouse model w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee8f75bc-84e4-58e6-af58-a1bfb7dc79d9
DOI: 10.1101/2020.03.27.012039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WNK1 regulates uterine homeostasis and its ability to support pregnancyDOI 10.1101/2020.03.27.012039Read

WNKs: protein kinases with a unique kinase domain.Semantic proximity Read

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.Semantic proximity Read

Transcriptomic Analysis Reveals Intrinsic Abnormalities in Endometrial PolypsSemantic proximity Read

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.Semantic proximity Read

The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early PregnancySemantic proximity Read

Human hypertension caused by mutations in WNK kinases.Semantic proximity Read

WNK kinases and the kidney.Semantic proximity Read

Exome sequencing identifies a novel gene, WNK1, for susceptibility to pelvic organ prolapse (POP).Semantic proximity Read

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.Semantic proximity Read

Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in miceSemantic proximity Read

WNK kinases and essential hypertension.Semantic proximity Read

The PNUTS-PP1 axis regulates endothelial aging and barrier function via SEMA3B suppressionSemantic proximity Read