Article

HES3-dependent regulatory functions in development and fusion-positive rhabdomyosarcoma

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> HES3/Her3 is a transcription factor that functions in non-canonical STAT3 signaling to promote the renewal of neural stem cells and has roles in multiple cancer contexts. To study its role in development and disease, we previously generated a CRISPR/Cas9 zebrafish knockout of her3 , the ortholog to human HES3. HES3 is also a cooperating gene in fusion-positive rhabdomyosarcoma, an aggressive pe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: baa3d559-0e4e-5834-a040-7f4a386d3f33
DOI: 10.64898/2026.05.05.723070

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HES3-dependent regulatory functions in development and fusion-positive rhabdomyosarcomaDOI 10.64898/2026.05.05.723070Read

Zebrafish <i>her3</i> knockout impacts developmental and cancer-related gene signaturesSemantic proximity Read

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivoSemantic proximity Read

Comparative modes of chromatin engagement by PAX::FOXO1 fusions in rhabdomyosarcomaSemantic proximity Read

Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive RhabdomyosarcomaSemantic proximity Read

Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and CancerSemantic proximity Read

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma.Semantic proximity Read

RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcomaSemantic proximity Read

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcomaSemantic proximity Read

PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain VulnerabilitySemantic proximity Read

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitorsSemantic proximity Read

Role of Myc family proteins in transcriptional regulation of growth and oncogenic transformation in fusion-positive rhabdomyosarcomaSemantic proximity Read

Fusion transcription factor dosage controls cell state in rhabdomyosarcomaSemantic proximity Read