Article

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma

2023-12-03

Abstract excerpt

<h4>Background</h4> Rhabdomyosarcoma (RMS), such as other childhood tumors, has witnessed treatment advancements in recent years. However, high-risk patients continue to face poor survival rates, often attributed to the presence of the PAX3/7-FOXO1 fusion proteins, which has been associated with metastasis and treatment resistance. Despite efforts to directly target these chimeric proteins, clinical success remai...

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Literature Corpus work: 95c1fdd1-0ec4-5b04-a140-b73c0808da53
DOI: 10.1101/2023.12.01.569530

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