Article

Role of Myc family proteins in transcriptional regulation of growth and oncogenic transformation in fusion-positive rhabdomyosarcoma

2025-12-02

Abstract excerpt

Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a PAX 3::FOXO1 (P3F) or PAX7::FOXO1 fusion gene. After finding that MYCN is required for P3F-induced oncogenic transformation in a human myoblast model of FP-RMS, we further investigated the role of Myc family proteins in FP-RMS. Expression studies revealed that myoblast models and a subset of FP-RMS lines have predominant MYCN or MYC expression whereas othe...

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Literature Corpus work: b8475497-694f-5048-9d8e-0dbce48f78d2
DOI: 10.64898/2025.12.01.690506

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