Article

Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

2025-05-21

Abstract excerpt

In the fusion-positive subset of rhabdomyosarcoma, the PAX3::FOXO1 oncoprotein is the most common fusion driver. We previously established a human myoblast system for inducible expression of PAX3::FOXO1. In the current study, we modulate PAX3::FOXO1 protein expression to understand the epigenetic and phenotypic functions at different PAX3::FOXO1 levels. Proliferative and oncogenic outcomes depend on PAX3::FOXO1 do...

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Literature Corpus work: 8f066acc-8e8a-53cb-89ee-c26a45b64be2
DOI: 10.1101/2025.05.16.654522

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