Article

Zebrafish <i>her3</i> knockout impacts developmental and cancer-related gene signatures

2022-02-26

Abstract excerpt

HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3 overexpression is predictive of reduced overall survival in patients with fusion-positive rhabdomyosarcoma, a pediatric cancer that resembles immature and undifferentiated skeletal muscle. However, the mechanisms of HES3 cooperation in fusion-positive rhabdomyosarcoma are unclear and are likely...

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Literature Corpus work: 22a47f73-dcb2-531b-9321-79f0ce3bc63d
DOI: 10.1101/2022.02.25.482038

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