Article

Single-chain and condensed-state behavior of hnRNPA1 from molecular simulations

2022-04-13

Abstract excerpt

Intrinsically disordered proteins (IDPs) are essential components for the formation of membraneless organelles, which play key functional and regulatory roles within biological systems. These complex assemblies form and dissolve spontaneously over time via liquid-liquid phase separation of IDPs. Mutations in their amino acid sequence can alter their phase behavior, which has been linked to the emergence of severe...

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Literature Corpus work: baa12059-4db6-5ced-ab02-298739e03d54
DOI: 10.1101/2022.04.13.488036

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