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Article

BRAF gene: From human cancers to developmental syndromes

24 Oct 2014

Abstract excerpt

The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better...

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PMID: 26150740
DOI: 10.1016/j.sjbs.2014.10.002

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