Article

<i>Ptpn14</i> Knockout Mice Reveal Critical Female-Specific Roles for the Hippo Pathway

2025-01-13

Abstract excerpt

<h4>ABSTRACT</h4> The Hippo pathway regulates many physiological processes, including development, tumor suppression, and wound healing. One understudied Hippo pathway component is PTPN14, an evolutionarily conserved tyrosine-phosphatase that inhibits YAP/TAZ. While an established tumor suppressor, PTPN14’s role in tissue homeostasis has remained unclear. We thus generated Ptpn14 -deficient mice and found that o...

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Literature Corpus work: ba2c5f4a-f82d-5d78-9eef-781baacf50b9
DOI: 10.1101/2025.01.13.632464

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