Back to search

Article

Transcriptomic Analysis of <i>Plac1</i> Ablation Reveals Broad Alterations in Signaling Pathways Essential for Prenatal Development and Overlap with a Preeclampsia-Associated Signature

2026-05-04

Abstract excerpt

Plac1 is an X-linked gene essential for placental and embryonic development. A knockout (KO) mouse model was used to define placental gene expression changes associated with Plac1 loss at E16.5 and E18.5 using gene expression microarray. Genes exhibiting at least a 1.5-fold change and FDR < 0.05 were considered significant. At E16.5, 717 genes were downregulated and 796 upregulated in KO placentas relative to wild...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
22c8d065-5cab-51a9-937e-2d2ce1f8bb47
DOI
10.64898/2026.04.30.721637
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transcriptomic Analysis of <i>Plac1</i> Ablation Reveals Broad Alterations in Signaling Pathways Essential for Prenatal Development and Overlap with a Preeclampsia-Associated SignatureDOI 10.64898/2026.04.30.721637
Plac1 (placenta-specific 1) is essential for normal placental and embryonic development.Semantic proximity
Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus.Semantic proximity
The Nexus of Prematurity, Birth Defects, and Intrauterine Growth Restriction: A Role for Plac1-Regulated PathwaysSemantic proximity
Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice1Semantic proximity
Plac8 and Plac9, novel placental-enriched genes identified through microarray analysisSemantic proximity
PLAC1, an Xq26 Gene with Placenta-Specific ExpressionSemantic proximity
Genome-wide expression profiling of placentas in the p57Kip2 model of pre-eclampsia.Semantic proximity
A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell ProcessesSemantic proximity
STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defectsSemantic proximity
<i>Cited1</i> Is Required in Trophoblasts for Placental Development and for Embryo Growth and SurvivalSemantic proximity
Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines.Semantic proximity
Placentation defects are highly prevalent in embryonic lethal mouse mutants.Semantic proximity
Select a neighboring publication to make it the new centre.