Article

Targeting <i>de novo</i> lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

2021-03-19

Abstract excerpt

Mutant KRAS (KM) is the most common oncogene in lung cancer (LC). KM regulates several metabolic networks, but their role in tumorigenesis is still not sufficiently characterized to be exploited in cancer therapy. To identify metabolic networks specifically deregulated in KMLC, we characterized the lipidome of genetically engineered LC mice, cell lines, patient derived xenografts and primary human samples. We als...

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Literature Corpus work: b9eb8be1-63b6-558d-82e3-1885048a82d2
DOI: 10.1101/2021.03.18.434804

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