Article

Allosteric deimmunisation of a <i>Salmonella</i> phosphatase enhances catalytic function

2025-11-17

Abstract excerpt

Genetically engineered Salmonella strains are promising vectors for cancer therapy, but their clinical use is limited by host immune responses. A key immunogenic antigen, the phosphatase PhoN, is metabolically essential for bacterial survival in the vitamin B6-depleted tumour microenvironment and thus cannot be simply deleted. While conventional deimmunisation targets surface residues, we present a strategy of al...

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Literature Corpus work: b9d8388d-555b-58be-a09c-92c912319969
DOI: 10.1101/2025.11.17.688463

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Allosteric deimmunisation of a <i>Salmonella</i> phosphatase enhances catalytic functionDOI 10.1101/2025.11.17.688463Read

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