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Article

Production of soluble and active microbial transglutaminase in Escherichia coli for site-specific antibody drug conjugation.

Protein science : a publication of the Protein Society - 1 Feb 2016

Rickert Mathias, Strop Pavel, Lui Victor, Melton-Witt Jody, Farias Santiago Esteban, Foletti Davide, Shelton David, Pons Jaume, Rajpal Arvind

Abstract excerpt

Applications of microbial transglutaminase (mTGase) produced from Streptomyces mobarensis (S. mobarensis) were recently extended from food to pharmaceutical industry. To use mTGase for clinical applications, like generation of site specific antibody drug conjugates, it would be beneficial to manufacture mTGase in Escherichia coli (E. coli). To date, attempts to express recombinant soluble and active S. mobarensis...

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Identifiers

PMID: 26481561
DOI: 10.1002/pro.2833
PMCID: PMC4815333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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