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Article

Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2017

Salvat Regina S, Verma Deeptak, Parker Andrew S, Kirsch Jack R, Brooks Seth A, Bailey-Kellogg Chris, Griswold Karl E

Abstract excerpt

Therapeutic proteins of wide-ranging function hold great promise for treating disease, but immune surveillance of these macromolecules can drive an antidrug immune response that compromises efficacy and even undermines safety. To eliminate widespread T-cell epitopes in any biotherapeutic and thereby mitigate this key source of detrimental immune recognition, we developed a Pareto optimal deimmunization library...

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Identifiers

PMID: 28607051
DOI: 10.1073/pnas.1621233114
PMCID: PMC5495236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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