Article

The strength of hERG inhibition by Erythromycin at different temperature might be due to its different critical binding sites on the channels

2024-01-31

Abstract excerpt

The human ether-a-go-go-related gene (hERG) inhibition is a serious cardiac safety issue. Although the inhibition of hERG by majority of compounds are stable, the strength of the inhibition of a few compounds, including Erythromycin, is remarkably rising from room temperature (RT) to physiological temperature (PT). Understanding the features of erythromycin against hERG could help us to decide which compounds are...

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Literature Corpus work: b9d5393b-e027-594a-aebc-67c308ef4c2f
DOI: 10.22541/au.170671032.22927942/v1

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