Back to search

Article

Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells

2020-03-02

Abstract excerpt

<title>Abstract</title> <p>Background Macrolides are clinically well-established class of antibiotics. Macrolides induce cardiotoxicity by blocking ether-a-go-go–related gene (ERG) potassium channels in cardiac myocytes. The aim of this study was to compare the effects of erythromycin, clarithromycin and azithromycin on cell viability and expression of ERG1 gene in H9c2 cells. Methods Cell viability and ERG1 gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9d00d3b9-e716-5207-a478-2ade230b56cb
DOI
10.21203/rs.2.20889/v2
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast CellsDOI 10.21203/rs.2.20889/v2
The strength of hERG inhibition by Erythromycin at different temperature might be due to its different critical binding sites on the channelsSemantic proximity
A genome-wide analysis of targets of macrolide antibiotics in mammalian cellsSemantic proximity
A novel mutation in hERG gene associated with azithromycin-induced acquired long QT syndrome.Semantic proximity
Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World PracticeSemantic proximity
Pharmacological corrections of the mutant hERG channels by posaconazole.Semantic proximity
The innate anti-viral effects of Azithromycin and other novel macrolidesSemantic proximity
Insights into erythromycin action from studies of its activity as inducer of resistance.Semantic proximity
Azithromycin Induces Neurotoxicity in Zebrafish by Interfering with the Vegf/Notch Signaling PathwaySemantic proximity
Drugs That Induce Repolarization Abnormalities Cause Bradycardia in ZebrafishSemantic proximity
Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.Semantic proximity
Select a neighboring publication to make it the new centre.