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Article

Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.

Human molecular genetics - 15 May 2018

Papadopoulos Vassilis E, Nikolopoulou Georgia, Antoniadou Ivi, Karachaliou Antonia, Arianoglou Giovanna, Emmanouilidou Evangelia, Sardi S Pablo, Stefanis Leonidas, Vekrellis Kostas

Abstract excerpt

Glucocerebrosidase gene (GBA) mutations are the most common genetic contributor to Parkinson's disease (PD) and are associated with decreased glucocerebrosidase (GCase) enzymatic activity in PD. PD patients without GBA mutations also exhibit lower levels of GCase activity in the central nervous system suggesting a potential contribution of the enzyme activity in disease pathogenesis, possibly by alteration of...

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PMID: 29547959
DOI: 10.1093/hmg/ddy075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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