Article
Glucocerebrosidase and Parkinson Disease: Molecular, Clinical, and Therapeutic Implications.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Oct 2018
Balestrino Roberta, Schapira Anthony H V
Abstract excerpt
Parkinson disease (PD) is a complex neurodegenerative disease characterised by multiple motor and non-motor symptoms. In the last 20 years, more than 20 genes have been identified as causes of parkinsonism. Following the observation of higher risk of PD in patients affected by Gaucher disease, a lysosomal disorder caused by mutations in the glucocerebrosidase (GBA) gene, it was discovered that mutations in this...
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