Article

A nanobody-based toolset to monitor and modify the mitochondrial GTPase Miro1

2021-12-10

Abstract excerpt

The mitochondrial outer membrane (MOM)-anchored GTPase Miro1, is a central player in mitochondrial transport and homeostasis. The dysregulation of Miro1 in amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) suggests that Miro1 may be a potential biomarker or drug target in neuronal disorders. However, the molecular functionality of Miro1 under (patho-) physiological conditions is poorly known. For a...

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Literature Corpus work: b9c61814-a045-5201-a73c-e1ddb7a005b6
DOI: 10.1101/2021.12.10.472061

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