Article

An improved molecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under pathological conditions

2021-04-01

Abstract excerpt

Membrane-less organelles (MLOs) formed by liquid-liquid phase separation (LLPS) play pivotal roles in biological processes. During LLPS, proteins and nucleotides are extremely condensed, resulting in changes of their conformation and biological functions. Disturbed LLPS homeostasis in MLOs cause fatal diseases such as amyotrophic lateral sclerosis. Therefore, it is important to detect changes of the degree of crow...

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Literature Corpus work: 282c30f8-ce71-5ee4-923a-4d8ceae926f8
DOI: 10.1101/2021.03.31.437991

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