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Article

Nanobodies as Novel Tools to Modulate Human Frataxin Stability and Function

2025-03-12

Abstract excerpt

<title>Abstract</title> <p> Iron-sulfur clusters are essential cofactors for hundreds of proteins. In eukaryotic cells, the biogenesis of most iron-sulfur clusters occurs in the mitochondria and involves the Cys desulfurase supercomplex, which is activated by frataxin (FXN). The decrease of FXN expression, stability, and/or function results in Friedreich's ataxia (FA), a rare disease affecting 1 in 50,000 people...

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Identifiers and source

Literature Corpus work
89ecc53a-335f-59ce-b631-8a0c8ffb15b4
DOI
10.21203/rs.3.rs-6122246/v1
Open publication

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Nanobodies as Novel Tools to Modulate Human Frataxin Stability and FunctionDOI 10.21203/rs.3.rs-6122246/v1
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