Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.

doi:10.1016/j.biopsych.2020.12.024

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Article

Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.

Biological psychiatry - 15 Jun 2021

Martin Joanna, Khramtsova Ekaterina A, Goleva Slavina B, Blokland Gabriëlla A M, Traglia Michela, Walters Raymond K, Hübel Christopher, Coleman Jonathan R I, Breen Gerome, Børglum Anders D, Demontis Ditte, Grove Jakob, Werge Thomas, Bralten Janita, Bulik Cynthia M, Lee Phil H, Mathews Carol A, Peterson Roseann E, Winham Stacey J, Wray Naomi, Edenberg Howard J, Guo Wei, Yao Yin, Neale Benjamin M, Faraone Stephen V, Petryshen Tracey L, Weiss Lauren A, Duncan Laramie E, Goldstein Jill M, Smoller Jordan W, Stranger Barbara E, Davis Lea K

Abstract excerpt

BACKGROUND: The origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic architecture within and between traits. METHODS: Using European ancestry genome-wide association summary statistics for 20 neuropsychiatric and behavioral traits, we tested for sex...

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Identifiers

PMID: 33648717
DOI: 10.1016/j.biopsych.2020.12.024
PMCID: PMC8163257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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