Article

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

2024-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (EwS) is a highly aggressive bone and soft-tissue associated cancer for which there are no effective targeted therapeutics available. Genetically, EwS is driven by aberrantly active EWSR1::ETS fusion transcription factors, most commonly EWSR1::FLI1. Despite their unique expression in EwS, all attempts to effectively target these fusion oncoproteins clinically were not yet successfu...

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Literature Corpus work: b99f72e5-333a-5303-8919-3d0d35094b2d
DOI: 10.1101/2024.04.24.590877

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