Article
STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors.
Molecular cancer research : MCR - 1 Jan 2012
Grunewald Thomas G P, Diebold Isabel, Esposito Irene, Plehm Stephanie, Hauer Kristina, Thiel Uwe, da Silva-Buttkus Patricia, Neff Frauke, Unland Rebekka, Müller-Tidow Carsten, Zobywalski Colette, Lohrig Katharina, Lewandrowski Urs, Sickmann Albert, Prazeres da Costa Olivia, Görlach Agnes, Cossarizza Andrea, Butt Elke, Richter Günther H S, Burdach Stefan
Abstract excerpt
Ewing tumors comprise the second most common type of bone-associated cancer in children and are characterized by oncogenic EWS/FLI1 fusion proteins and early metastasis. Compelling evidence suggests that elevated levels of intracellular oxidative stress contribute to enhanced aggressiveness of numerous cancers, possibly including Ewing tumors. Using comprehensive microarray analyses and RNA interference, we...
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