Article

N’-(1-phenylethylidene)-benzohydrazide cytotoxicity is LSD1 independent and linked to Fe-S cluster disruption in Ewing sarcoma

2025-06-26

Abstract excerpt

<h4>ABSTRACT</h4> The noncompetitive LSD1 inhibitors SP-2509 and SP-2577 are N’-(1-phenylethylidene)-benzohydrazides that display potent activity in Ewing sarcoma. They block transcriptional regulation of the causative oncogenic fusion protein, EWSR1::FLI1, and cause cell death. However, SP-2509 and SP-2577 are the only LSD1 inhibitors active in Ewing sarcoma; other LSD1 inhibitors have little effect. Studies fro...

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Literature Corpus work: 5aff6236-bd02-5422-8955-ff104b21547c
DOI: 10.1101/2025.06.20.660795

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