Article

<i>SLFN11</i> Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma

2025-05-10

Abstract excerpt

Ewing sarcoma (EWS) is an aggressive cancer in adolescents and young adults with frequent relapse rates and poor outcomes in recurrent or metastatic cases. Schlafen family member 11 ( SLFN11 ) gene is associated with the sensitivity to DNA-damaging agents (DDAs). The knockout of SLFN11 is associated with acquired chemoresistance in both cell lines and preclinical models. Here, we aimed to elucidate the metabolic...

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Literature Corpus work: 8669a90a-3ec2-53ee-8946-a5b8da0a01eb
DOI: 10.1101/2025.05.09.652501

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