Article

A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer

2023-10-27

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> PDAC is characterized by significant matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, it is not clear the connection between matrix stiffness and the Warburg effect and the mechanisms of action in tumor progression. <h4>METHODS</h4> The relationship between matrix stiffness and the Warburg effect was investigated from clinical, cellular,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c9c30a3-76aa-53c9-9043-0b0185426bef
DOI: 10.1101/2023.10.27.564288

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancerDOI 10.1101/2023.10.27.564288Read

A positive feedback between HIF1α and lysyl oxidase-like 2 dictates the Warburg Effect in Pancreatic CancerSemantic proximity Read

Tumor heterogeneity: An oncogenic driver of PDAC progression and therapy resistance under stress conditions.Semantic proximity Read

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets.Semantic proximity Read

LncRNA YIYA enhances pancreatic cancer proliferation under high-glucose conditions through RAS–PKM2–mediated metabolic reprogramming that reinforces the Warburg phenotypeSemantic proximity Read

Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic adenocarcinomaSemantic proximity Read

Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potentialSemantic proximity Read

[A Review of Metabolic Stress and Development of Pancreatic Cancer].Semantic proximity Read

Monocarboxylate Transporters are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

MiR-519a/522-5p from pancreatic cancer-secreted exosomes promotes tumor invasion by enhancing Warburg effectSemantic proximity Read

Drivers of the Warburg phenotype.Semantic proximity Read

Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer.Semantic proximity Read

Tumor–stromal metabolic crosstalk in pancreatic cancerSemantic proximity Read