Article

Pathogenic human mitochondrial tRNA variants impair RNA processing by compromising 5′ leader removal

2026-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Human mitochondrial genome (mtDNA) encodes multiple proteins in the oxidative phosphorylation complexes as well as the ribosomal and transfer RNAs (tRNAs) needed for in situ translation. These genes are transcribed from only three promoters, producing polycistronic transcripts that are co-transcriptionally cleaved by mitochondrial RNase enzymes to release majority of individual gene products. t...

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Literature Corpus work: fc607200-03de-5cea-9767-e90712b25ec5
DOI: 10.64898/2026.03.25.714317

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