Article

A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection

2023-07-07

Abstract excerpt

<h4>Summary</h4> Several vaccines targeting bacterial pathogens show reduced efficacy in the context of intercurrent viral infection indicating a new vaccinology approach is required to protect against such superinfections. To find antigens for the human pathogen Streptococcus pneumoniae that are effective following influenza infection, we performed CRISPRi-seq in a murine model of superinfection and identified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9671553-a9b9-5f93-8cfb-1a3c0cb53a1d
DOI: 10.1101/2023.07.07.548156

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfectionDOI 10.1101/2023.07.07.548156Read

The interaction between influenza vaccination and nasal pneumococcal colonization alters airway T cell responses and alveolar macrophage activationSemantic proximity Read

Nasopharyngeal colonisation by <i>Streptococcus pneumoniae</i> enhances host anti-viral responses to respiratory virus infectionSemantic proximity Read

Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191Semantic proximity Read

A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant.Semantic proximity Read

Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection nichesSemantic proximity Read

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin VariantSemantic proximity Read

A live‐attenuated pneumococcal vaccine elicits CD4+ T‐cell dependent class switching and provides serotype independent protection against acute otitis mediaSemantic proximity Read

Use of a Whole Genome Approach To Identify Vaccine Molecules Affording Protection against Streptococcus pneumoniae InfectionSemantic proximity Read

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae.Semantic proximity Read

Comprehensive vaccine design for commensal disease progressionSemantic proximity Read

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriageSemantic proximity Read

A multiomics analysis of direct interkingdom dynamics between influenza A virus and <i>Streptococcus pneumoniae</i> uncovers host-independent changes to bacterial virulence fitnessSemantic proximity Read