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Article

A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant.

Cell reports - 20 Jul 2021

Zhao Bali, Yang Jingyi, He Bing, Li Xian, Yan Hu, Liu Shuning, Yang Yi, Zhou Dihan, Liu Bowen, Fan Xuxu, Zhong Maohua, Zhang Ejuan, Zhang Fan, Zhang Yue, Chen Yao-Qing, Jiang Shibo, Yan Huimin

Abstract excerpt

Respiratory syncytial virus (RSV) is a major cause of serious acute lower respiratory tract infection in infants and the elderly. The lack of a licensed RSV vaccine calls for the development of vaccines with other targets and vaccination strategies. Here, we construct a recombinant protein, designated P-KFD1, comprising RSV phosphoprotein (P) and the E.-coli-K12-strain-derived flagellin variant KFD1. Intranasal...

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Identifiers

PMID: 34289371
DOI: 10.1016/j.celrep.2021.109401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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