Article
Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.
PloS one - 1 Jan 2012
Ippolito Gregory C, Hoi Kam Hon, Reddy Sai T, Carroll Sean M, Ge Xin, Rogosch Tobias, Zemlin Michael, Shultz Leonard D, Ellington Andrew D, Vandenberg Carla L, Georgiou George
Abstract excerpt
Immunodeficient mice reconstituted with human hematopoietic stem cells enable the in vivo study of human hematopoiesis. In particular, NOD-scid-IL2Rγ(null) engrafted mice have been shown to have reasonable levels of T and B cell repopulation and can mount T-cell dependent responses; however, antigen-specific B-cell responses in this model are generally poor. We explored whether developmental defects in the...
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