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Article

Insights into a Crucial Role of TRIP13 in Human Cancer

1 Jan 2019

Abstract excerpt

Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) plays a key role in regulating mitotic processes, including spindle assembly checkpoint and DNA repair pathways, which may account for Chromosome instability (CIN). As CIN is a predominant hallmark of cancer, TRIP13 may act as a tumor susceptibility locus. Amplification of TRIP13 has been observed in various human cancers and implicated in several aspects...

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PMID: 31321001
DOI: 10.1016/j.csbj.2019.06.005

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