Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The oncogenic E3 ligase TRIP12 suppresses epithelial–mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2

7 May 2021

Abstract excerpt

Thyroid hormone receptor interactor 12 (TRIP12) is an E3 ligase most notably involved in the proteolytic degradation of the tumor suppressor p14ARF. Through this process, it is proposed that TRIP12 plays an oncogenic role in tumor initiation and growth. However, its role in other cancer processes is unknown. In this study, using publicly available cancer patient datasets, we found TRIP12 to be associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33963176
DOI: 10.1038/s41420-021-00479-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The oncogenic E3 ligase TRIP12 suppresses epithelial–mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2PMID 33963176Read ↗

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2Semantic proximity Read ↗

E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions.Semantic proximity Read ↗

TRIP13 promotes lung cancer cell growth and metastasis through AKT/mTORC1/c-Myc signalingSemantic proximity Read ↗

TRIM family contribute to tumorigenesis, cancer development, and drug resistanceSemantic proximity Read ↗

Thyroid Hormone Receptor Interacting Protein 13 Is Associated with Prognosis and Immunotherapy Efficacy in Human Cancers: A Pan-cancer AnalysisSemantic proximity Read ↗

Insights into a Crucial Role of TRIP13 in Human CancerSemantic proximity Read ↗

Tumor suppressor SET9 guides the epigenetic plasticity of breast cancer cells and serves as an early-stage biomarker for predicting metastasis.Semantic proximity Read ↗

ZEB2 regulates endocrine therapy sensitivity and metastasis in luminal a breast cancer cells through a non-canonical mechanismSemantic proximity Read ↗

TRIP13 promotes proliferation and invasion of epithelial ovarian cancer cells through Notch signaling pathway.Semantic proximity Read ↗

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10Semantic proximity Read ↗

TRIM28 in cancer and cancer therapySemantic proximity Read ↗

Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.