Article

Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue

2024-01-16

Abstract excerpt

<h4>ABSTRACT</h4> The selective removal of dysfunctional mitochondria, a process termed mitophagy, is critical for cellular health and impairments have been linked to aging, Parkinson disease, and other neurodegenerative conditions. A central mitophagy pathway is orchestrated by the ubiquitin (Ub) kinase PINK1 together with the E3 Ub ligase PRKN/Parkin. The decoration of damaged mitochondrial domains with phospho...

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Literature Corpus work: b941eea4-c71a-5940-851d-2bb4bdd23716
DOI: 10.1101/2024.01.15.575715

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