Article
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.
Autophagy - 1 Jan 2018
Hou Xu, Fiesel Fabienne C, Truban Dominika, Castanedes Casey Monica, Lin Wen-Lang, Soto Alexandra I, Tacik Pawel, Rousseau Linda G, Diehl Nancy N, Heckman Michael G, Lorenzo-Betancor Oswaldo, Ferrer Isidre, Arbelo José M, Steele John C, Farrer Matthew J, Cornejo-Olivas Mario, Torres Luis, Mata Ignacio F, Graff-Radford Neill R, Wszolek Zbigniew K, Ross Owen A, Murray Melissa E, Dickson Dennis W, Springer Wolfdieter
Abstract excerpt
Although exact causes of Parkinson disease (PD) remain enigmatic, mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuron susceptibility in both familial and sporadic PD. Two genes associated with recessive, early-onset PD encode the ubiquitin (Ub) kinase PINK1 and the E3 Ub ligase PRKN/PARK2/Parkin, which together orchestrate a protective mitochondrial quality control...
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