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Development and validation of a sensitive sandwich ELISA against human PINK1

6 Feb 2025

Abstract excerpt

The ubiquitin kinase and ligase PINK1 and PRKN together label damaged mitochondria for their elimination in lysosomes by selective autophagy (mitophagy). This cytoprotective quality control pathway is genetically linked to familial Parkinson disease but is also altered during aging and in other neurodegenerative disorders. However, the molecular mechanisms of these mitophagy changes remain uncertain. In healthy...

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Identifiers

PMID: 39912496
DOI: 10.1080/15548627.2025.2457915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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