Article

Rewiring Glucose Metabolism Improves 5-FU Efficacy in Glycolytic p53-Deficient Colorectal Tumors

2021-12-10

Abstract excerpt

<title>Abstract</title> <p>5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), however response rates in patients are limited to 50%. Unexpectedly, the molecular mechanisms by which 5-FU ultimately induces toxicity remain debated, limiting the development of strategies to improve its efficacy. How fundamental aspects of cancer, such as driver mutations and phenotypic intra-tumor het...

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Literature Corpus work: b927ba50-6e51-5a09-b98a-dcf569dd685d
DOI: 10.21203/rs.3.rs-1054076/v1

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