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Article

5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits.

Oncotarget - 8 Dec 2015

Denise Corti, Paoli Paolo, Calvani Maura, Taddei Maria Letizia, Giannoni Elisa, Kopetz Scott, Kazmi Syed Mohammad Ali, Pia Morelli Maria, Pettazzoni Piergiorgio, Sacco Elena, Caselli Anna, Vanoni Marco, Landriscina Matteo, Cirri Paolo, Chiarugi Paola

Abstract excerpt

Despite marked tumor shrinkage after 5-FU treatment, the frequency of colon cancer relapse indicates that a fraction of tumor cells survives treatment causing tumor recurrence. The majority of cancer cells divert metabolites into anabolic pathways through Warburg behavior giving an advantage in terms of tumor growth. Here, we report that treatment of colon cancer cell with 5-FU selects for cells with mesenchymal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26527315
DOI: 10.18632/oncotarget.5991
PMCID: PMC4747183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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