Article

Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors

2021-11-16

Abstract excerpt

5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC). Response rates in patients are, however, limited to 50%. Despite the importance of 5-FU, the molecular mechanisms by which it induces toxicity remain unclear, limiting the development of strategies to improve efficacy. How fundamental aspects of cancer, such as driver mutations and phenotypic intra-tumor heterogeneity, relate to the...

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Literature Corpus work: 820925ba-5039-5185-8f68-b25ebcec4ca3
DOI: 10.1101/2021.11.11.468185

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