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Article

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.

Oncotarget - 26 Jul 2016

Aguilera Oscar, Muñoz-Sagastibelza María, Torrejón Blanca, Borrero-Palacios Aurea, Del Puerto-Nevado Laura, Martínez-Useros Javier, Rodriguez-Remirez María, Zazo Sandra, García Estela, Fraga Mario, Rojo Federico, García-Foncillas Jesús

Abstract excerpt

KRAS mutation is often present in many hard-to-treat tumors such as colon and pancreatic cancer and it is tightly linked to serious alterations in the normal cell metabolism and clinical resistance to chemotherapy.In 1931, the winner of the Nobel Prize in Medicine, Otto Warburg, stated that cancer was primarily caused by altered metabolism interfering with energy processing in the normal cell. Increased cell...

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Identifiers

PMID: 27323830
DOI: 10.18632/oncotarget.10087
PMCID: PMC5216991

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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