Article

Inhibition of SOD1 trimerization is a novel drug target for ALS disease

2024-12-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease that begins with cell death of motor neurons in the spinal cord and leads to death from respiratory distress (breathing failure). Most of patients are sporadic type but several genetic causes have been reported. One well-identified genetic variation is a mutation in the SOD1 gene. Indeed...

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Literature Corpus work: b8fe95ef-5758-5e59-9647-39dc146893e0
DOI: 10.21203/rs.3.rs-5394854/v1

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