Article

Selective removal of misfolded SOD1 delays disease onset in a mouse model of amyotrophic lateral sclerosis

2023-02-02

Abstract excerpt

<title>Abstract</title> <p>Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. There is no cure currently. The discovery that mutations in the gene <italic>SOD1</italic> are a cause of ALS marks a breakthrough for the search of effective treatments for ALS. SOD1 is an antioxidant that is highly expressed in motor neurons. Human SOD1 is prone to aberrant modifications. Famil...

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Literature Corpus work: f8fa84f1-4454-5df7-97c0-d925212f916b
DOI: 10.21203/rs.3.rs-2507778/v1

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