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Article

SOD1 oligomers in amyotrophic lateral sclerosis.

Current opinion in structural biology - 1 Feb 2021

Choi Esther S, Dokholyan Nikolay V

Abstract excerpt

Identifying nonnative, trimeric forms of SOD1 trimers as the toxic species, rather than large aggregates revolutionizes our understanding of ALS pathophysiology. Large protein aggregates, what was previously thought as the central cause of neurodegeneration, play protective role and are not responsible for neuronal death. SOD1 trimers are implicated at the molecular, cellular, and organismal level. Understanding...

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Identifiers

PMID: 33465527
DOI: 10.1016/j.sbi.2020.12.002
PMCID: PMC7965251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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