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Article

Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model.

Communications biology - 15 Dec 2021

Woo Tae-Gyun, Yoon Min-Ho, Kang So-Mi, Park Soyoung, Cho Jung-Hyun, Hwang Young Jun, Ahn Jinsook, Jang Hyewon, Shin Yun-Jeong, Jung Eui-Man, Ha Nam-Chul, Kim Bae-Hoon, Kwon Yonghoon, Park Bum-Joon

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain of its toxic property are the major culprit of familial ALS (fALS). The abnormal SOD1 aggregation in the motor neurons has been suggested as the major pathological hallmark of ALS patients. However, the development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34912047
DOI: 10.1038/s42003-021-02862-z
PMCID: PMC8674338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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