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Article

Investigating the impact of SOD1 mutations on amyotrophic lateral sclerosis progression and potential drug repurposing through in silico analysis.

Journal of biomolecular structure & dynamics - 1 Jan 2026

Alzahrani A Khuzaim, Imran Mohd, Alshrari Ahmed S

Abstract excerpt

Superoxide dismutase 1 (SOD1) is a vital enzyme responsible for attenuating oxidative stress through its ability to facilitate the dismutation of the superoxide radical into oxygen and hydrogen peroxide. The progressive loss of motor neurons characterize amyotrophic lateral sclerosis (ALS), a crippling neurodegenerative disease that is caused by mutations in the SOD1 gene. In this study, in silico mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39673548
DOI: 10.1080/07391102.2024.2439577

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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