Toxic SOD1 trimers are off-pathway in the formation of amyloid-like fibrils in ALS.

doi:10.1016/j.bpj.2022.04.037

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Article

Toxic SOD1 trimers are off-pathway in the formation of amyloid-like fibrils in ALS.

Biophysical journal - 7 Jun 2022

Hnath Brianna, Dokholyan Nikolay V

Abstract excerpt

Accumulation of insoluble amyloid fibrils is widely studied as a critical factor in the pathology of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Misfolded Cu, Zn superoxide dismutase (SOD1) was the first protein linked to ALS, and non-native SOD1 trimeric oligomers were recently linked to cytotoxicity, while larger oligomers were...

Topics

Amyloid
Amyotrophic Lateral Sclerosis
Humans
Mutation
Neurodegenerative Diseases
Superoxide Dismutase
Superoxide Dismutase-1

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Identifiers

PMID: 35505609
DOI: 10.1016/j.bpj.2022.04.037
PMCID: PMC9247475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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